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Factores de virulencia de Mycobacterium tuberculosis

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dc.contributor.author Maulén, Nancy P.
dc.date.accessioned 2016-07-18T19:36:36Z
dc.date.available 2016-07-18T19:36:36Z
dc.date.issued 2011-12
dc.identifier.citation Rev. méd. Chile vol.139 no.12 Santiago Dec. 2011 es
dc.identifier.issn 0034-9887
dc.identifier.other http://dx.doi.org/10.4067/S0034-98872011001200012
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/1090
dc.description Indexación: Web of Science; Scielo es
dc.description.abstract Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. The increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. The understanding of the mechanisms of transmission, pathogenesis and virulence of M. tuberculosis is important. The analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. Environmental stimuli such as pH, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. The molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models. es
dc.description.uri http://ref.scielo.org/vztc48
dc.language.iso es es
dc.publisher Sociedad Médica de Santiago es
dc.subject Etiology es
dc.subject Mycobacterium tuberculosis es
dc.subject Virulence es
dc.subject Pathophysiology es
dc.title Factores de virulencia de Mycobacterium tuberculosis es
dc.title.alternative Virulence factors of Mycobacterium tuberculosis es
dc.type Article es

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