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dc.contributor.authorMaulén, Nancy P.
dc.date.accessioned2016-07-18T19:36:36Z
dc.date.available2016-07-18T19:36:36Z
dc.date.issued2011-12
dc.identifier.citationRev. méd. Chile vol.139 no.12 Santiago Dec. 2011es
dc.identifier.issn0034-9887
dc.identifier.otherhttp://dx.doi.org/10.4067/S0034-98872011001200012
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/1090
dc.descriptionIndexación: Web of Science; Scieloes
dc.description.abstractMycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. The increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. The understanding of the mechanisms of transmission, pathogenesis and virulence of M. tuberculosis is important. The analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. Environmental stimuli such as pH, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. The molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models.es
dc.description.urihttp://ref.scielo.org/vztc48
dc.language.isoeses
dc.publisherSociedad Médica de Santiagoes
dc.subjectEtiologyes
dc.subjectMycobacterium tuberculosises
dc.subjectVirulencees
dc.subjectPathophysiologyes
dc.titleFactores de virulencia de Mycobacterium tuberculosises
dc.title.alternativeVirulence factors of Mycobacterium tuberculosises
dc.typeArticlees


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