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Purinergic Signaling as a Regulator of Th17 Cell Plasticity

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dc.contributor.author Fernández, Dominique
dc.contributor.author Flores-Santibáñez, Felipe
dc.contributor.author Neira, Jocelyn
dc.contributor.author Osorio-Barrios, Francisco
dc.contributor.author Tejón, Gabriela
dc.contributor.author Nuñez, Sarah
dc.contributor.author Hidalgo, Yessia
dc.contributor.author Fuenzalida, Maria Jose
dc.contributor.author Meza, Daniel
dc.contributor.author Ureta, Gonzalo
dc.contributor.author Lladser, Alvaro
dc.contributor.author Pacheco, Rodrigo
dc.contributor.author Acuña-Castillo, Claudio
dc.contributor.author Guixé, Victoria
dc.contributor.author Quintana, Francisco J.
dc.contributor.author Bono, Maria Rosa
dc.contributor.author Rosemblatt, Mario
dc.contributor.author Sauma, Daniela
dc.date.accessioned 2016-07-22T15:22:42Z
dc.date.available 2016-07-22T15:22:42Z
dc.date.issued 2016-06
dc.identifier.citation PLoS ONE 11(6): e0157889 es
dc.identifier.issn 1932-6203
dc.identifier.other http://dx.doi.org/10.1371/journal.pone.0157889
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/1138
dc.description Indexación: Web of Science es
dc.description.abstract T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation. Recent evidence, supporting the notion of a functional and phenotypic instability of Th17 cells, has shown that Th17 differentiate into type 1 regulatory (Tr1) T cells during the resolution of intestinal inflammation. Moreover, it has been suggested that the expression of CD39 ectonucleotidase endows Th17 cells with immunosuppressive properties. However, the exact role of CD39 ectonucleotidase in Th17 cells has not been studied in the context of intestinal inflammation. Here we show that Th17 cells expressing CD39 ectonucleotidase can hydrolyze ATP and survive to ATP-induced cell death. Moreover, in vitro-generated Th17 cells expressing the CD39 ectonucleotidase produce IL-10 and are less pathogenic than CD39 negative Th17 cells in a model of experimental colitis in Rag-/- mice. Remarkably, we show that CD39 activity regulates the conversion of Th17 cells to IL-10-producing cells in vitro, which is abrogated in the presence of ATP and the CD39-specific inhibitor ARL67156. All these data suggest that CD39 expression by Th17 cells allows the depletion of ATP and is crucial for IL-10 production and survival during the resolution of intestinal inflammation. es
dc.description.uri http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157889
dc.language.iso en es
dc.publisher PUBLIC LIBRARY SCIENCE es
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject INFLAMMATORY-BOWEL-DISEASE es
dc.subject PATHOGENIC T(H)17 CELLS es
dc.subject CYTOKINE GM-CSF es
dc.subject T-CELLS es
dc.subject CROHNS-DISEASE es
dc.subject ADENOSINE GENERATION es
dc.subject IMMUNE SUPPRESSION es
dc.subject ADAPTIVE IMMUNITY es
dc.subject TYPE-1 CELLS es
dc.subject TGF-BETA es
dc.title Purinergic Signaling as a Regulator of Th17 Cell Plasticity es
dc.type Article es


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https://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/