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Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells

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dc.contributor.author Espinoza Catalán, Luis
dc.contributor.author Madrid Villegas, Alejandro
dc.contributor.author Taborga Liber, Lautaro
dc.contributor.author Villena García, Joan
dc.contributor.author Cuellar Fritis, Mauricio
dc.contributor.author Carrasco Altamirano, Héctor
dc.date.accessioned 2013-10-22T18:50:38Z
dc.date.accessioned 2016-05-24T20:22:41Z
dc.date.available 2013-10-22T18:50:38Z
dc.date.available 2016-05-24T20:22:41Z
dc.date.issued 2010
dc.identifier.citation Journal of the Chilean Chemical Society, Vol. 55, N° 2, pp. 219-222, 2010.
dc.identifier.issn ISSN: 0717-9707
dc.identifier.other DOI: 10.4067/S0717-97072010000200016
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/1943
dc.description Indexación: Scielo
dc.description.abstract Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells). en
dc.description.uri http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016&nrm=iso
dc.language.iso en
dc.publisher Sociedad Chilena de Química
dc.subject Antiproliferative activity
dc.subject Safrole derivatives
dc.subject Synthesis
dc.title Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells
dc.type Artículo de revista
dc.rights.holder © 2013 Sociedad Chilena de Química


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