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Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis

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dc.contributor.author Tischler, Nicole D.
dc.contributor.author Fernández, Jorge
dc.contributor.author Müller, Ilse
dc.contributor.author Martínez, Rodrigo
dc.contributor.author Galeno, Héctor
dc.contributor.author Villagra, Eliecer
dc.contributor.author Mora, Judith
dc.contributor.author Ramírez, Eugenio
dc.contributor.author Rosemblatt, Mario
dc.contributor.author Valenzuela, Pablo D.T.
dc.date.accessioned 2014-11-26T21:46:38Z
dc.date.accessioned 2016-05-24T19:54:04Z
dc.date.available 2014-11-26T21:46:38Z
dc.date.available 2016-05-24T19:54:04Z
dc.date.issued 2003
dc.identifier.citation Biological Research, Vol.36 N° 2. Santiago, 2003. es
dc.identifier.issn 0716-9760
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/2544
dc.description Indexación: Scielo es
dc.description.abstract We report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%. These genome segments code for a nucleocapsid protein of 428 amino acids, a glycoprotein precursor protein of 1,138 amino acids and a RNA-dependent RNA polymerase of 2,152 amino acids. In addition, the genome also has other ORFs coding for putative proteins of 34 to 103 amino acids. The encoded proteins have greater than 98% overall similarity with the proteins of Andes virus isolates AH-1 and Chile R123. Among other sequenced Hantavirus, CHI-7913 is more closely related to Sin Nombre virus, with an overall protein similarity of 92%. The characteristics of the encoded proteins of this isolate, such as hydrophobic domains, glycosylation sites, and conserved amino acid motifs shared with other Hantavirus and other members of the Bunyaviridae family, are identified and discussed. es
dc.language.iso en es
dc.publisher Sociedad de Biología de Chile es
dc.subject Hantavirus, genome sequence, RNA polymerase, human isolate es
dc.title Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis es
dc.type Article es


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