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Proteína Morfogenética Ósea y su Opción como Tratamiento de la Fisura Alveolar

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dc.contributor.author Uribe, F.
dc.contributor.author Cantín, M.
dc.contributor.author Alister, J.P.
dc.contributor.author Vilos, C.
dc.contributor.author Fariña, R.
dc.contributor.author Olate, S.
dc.date.accessioned 2017-10-26T16:14:02Z
dc.date.available 2017-10-26T16:14:02Z
dc.date.issued 2017-03
dc.identifier.citation Int. J. Morphol. vol.35 no.1 Temuco Mar. 2017 es_CL
dc.identifier.issn 0717-9502
dc.identifier.other http://dx.doi.org/10.4067/S0717-95022017000100049
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/4477
dc.description Indexación: Scopus; Scielo. es_CL
dc.description.abstract Bone morphogenetic protein (BMP) is an endogenous protein that has shown significant effects in the promotion of bone formation. BMP also has been described in the reconstruction of traumatic and pathological bone defects, including alveolar cleft, alveolar ridge augmentation, maxillary sinus elevation, and applications in post-extraction alveolus graft, and peri-implant surgery among others. Despite the advantages associated with the use of BMP, currently is applied in combination with collagen matrices, which has certain properties such as low mechanical resistance and a high burst initial release that diminish its effectiveness in bone formation. In this context, the development of novel systems with greater mechanical resistance and prolonged release of BMP, that lead to chemotaxis of mesenchymal cells, following by its differentiation to osteoblasts represents a major challenge that holds outstanding clinical potential for the stimulation of bone formation. In this paper, we describe the use of BMP for the reconstruction of alveolar clefts, and its advantages being administrated in polymeric microparticles as sustain release system with promising applications in the stimulation of bone formation. es_CL
dc.description.uri http://ref.scielo.org/ps5w6z
dc.language.iso es es_CL
dc.publisher Sociedad Chilena de Anatomía es_CL
dc.subject Proteína morfogenética ósea es_CL
dc.subject rhBMP-2 es_CL
dc.subject Fisura alveolar es_CL
dc.subject Micropartículas es_CL
dc.title Proteína Morfogenética Ósea y su Opción como Tratamiento de la Fisura Alveolar es_CL
dc.title.alternative Bone Morphogenetic Protein and its Option as an Alveolar Cleft Treatment es_CL
dc.type Article es_CL

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