Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica
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Fecha
2017-04
Profesor/a Guía
Facultad/escuela
Idioma
es
Título de la revista
ISSN de la revista
Título del volumen
Editor
Sociedad Médica de Santiago
Nombre de Curso
Licencia CC
Attribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.en
Resumen
Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
Notas
Indexación: Scopus.
Palabras clave
Pharmacogenetics, Pharmacokinetics, Pharmacogenomic variants, Polymorphisms, Genetic
Citación
Rev. méd. Chile vol.145 no.4 Santiago Apr. 2017