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dc.contributor.authorQuiñones, L.
dc.contributor.authorRoco, Á.
dc.contributor.authorCayún, J.P.
dc.contributor.authorEscalante, P.
dc.contributor.authorMiranda, C.
dc.contributor.authorVarela, N.
dc.contributor.authorMeneses, F.
dc.contributor.authorGallegos, B.
dc.contributor.authorZaruma-Torres, F.
dc.contributor.authorLares-Asseff, I.
dc.date.accessioned2018-01-08T15:42:50Z
dc.date.available2018-01-08T15:42:50Z
dc.date.issued2017-04
dc.identifier.citationRev. méd. Chile vol.145 no.4 Santiago Apr. 2017es_CL
dc.identifier.issn0034-9887
dc.identifier.otherhttp://dx.doi.org/10.4067/S0034-98872017000400009
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/5040
dc.descriptionIndexación: Scopus.es_CL
dc.description.abstractPharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.es_CL
dc.description.urihttp://ref.scielo.org/4y6n8m
dc.language.isoeses_CL
dc.publisherSociedad Médica de Santiagoes_CL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectPharmacogeneticses_CL
dc.subjectPharmacokineticses_CL
dc.subjectPharmacogenomic variantses_CL
dc.subjectPolymorphismses_CL
dc.subjectGenetices_CL
dc.titleFarmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínicaes_CL
dc.title.alternativeClinical applications of pharmacogenomicses_CL
dc.typeArticlees_CL
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)


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