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Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation

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dc.contributor.author Jain, J.
dc.contributor.author Moreno, J.
dc.contributor.author Andaur, R.
dc.contributor.author Armisen, R.
dc.contributor.author Morales, D.
dc.contributor.author Marcelain, K.
dc.contributor.author Avaria, G.
dc.contributor.author Bora, B.
dc.contributor.author Davis, S.
dc.contributor.author Pavez, C.
dc.contributor.author Soto, L.
dc.date.accessioned 2018-02-01T20:02:20Z
dc.date.available 2018-02-01T20:02:20Z
dc.date.issued 2017-08
dc.identifier.citation AIP Advances. Volume 7, Issue 8, 1 August 2017, Article number 085121 es_CL
dc.identifier.issn 2158-3226
dc.identifier.other DOI: 10.1063/1.4994655
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/5243
dc.description Indexación: Web of Science; Scopus. es_CL
dc.description.abstract Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely "PF-400J", was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research. es_CL
dc.description.uri http://recursosbiblioteca.unab.cl:2296/doi/pdf/10.1063/1.4994655
dc.language.iso en es_CL
dc.publisher American Institute of Physics Inc. es_CL
dc.subject BEAM EMISSION es_CL
dc.subject ENERGY es_CL
dc.title Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation es_CL
dc.type Article es_CL

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