Recent Submissions

  • TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia 

    Gatica, Sebastian; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos-Meza, Felipe; Echeverria, Cesar; Cabello-Verrugio, Claudio; Varela, Diego; Simon, Felipe (Springer Nature, 2020-02)
    Sepsis is the main cause of mortality in patients admitted to intensive care units. During sepsis, endothelial permeability is severely augmented, contributing to renal dysfunction and patient mortality. Ca2+ influx and ...
  • Transient receptor potential vanilloid 1 expression mediates capsaicin-induced cell death 

    Ramírez-Barrantes, R.; Córdova, C.; Gatica, S.; Rodriguez, B.; Lozano, C.; Marchant, I.; Echeverria, C.; Simon, F.; Olivero, P. (Frontiers Media S.A., 2018-06)
    The transient receptor potential (TRP) ion channel family consists of a broad variety of non-selective cation channels that integrate environmental physicochemical signals for dynamic homeostatic control. Involved in a ...
  • Muscularity and strength affect individual variation in self-perception of fighting ability in men 

    Muñoz-Reyes, J.A.; Polo, P.; Rodríguez-Sickert, C.; Pavez, P.; Valenzuela, N.; Ramírez-Herrera, O. (Frontiers Media S.A., 2019-01)
    Objective: There is evidence that competitive conflicts are the main form of intrasexual competition among men. The capacity to recognize visual cues of fighting ability in competitors is thought to be an important ...
  • Draft Whole-Genome Sequences of 51 Campylobacter jejuni and 12 Campylobacter coli Clinical Isolates from Chile 

    Bravo, V.; Varela, C.; Porte, L.; Weitzel, T.; Kastanis, G.J.; Balkey, M.; Blondel, C.J.; Gonzalez-Escalona, N. (American Society for Microbiology, 2020-04)
    Campylobacter species are the leading cause of gastroenteritis worldwide and an emerging threat in developing countries. Here, we report the draft whole-genome sequences of 51 Campylobacter jejuni and 12 Campylobacter coli ...
  • A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study 

    Roco, A.; Nieto, E.; Suárez, M.; Rojo, M.; Bertoglia, M.P.; Verón, G.; Tamayo, F.; Arredondo, A.; Cruz, D.; Muñoz, J.; Bravo, G; Salas, P.; Mejías, F.; Godoy, G.; Véliz, P.; Quiñones, L.A. (Frontiers Media S.A., 2020-04)
    Background: Vitamin K antagonists (VKA) are used as prophylaxis for thromboembolic events in patients with cardiovascular diseases. The most common VKA are warfarin and acenocoumarol. These drugs have a narrow therapeutic ...
  • Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division 

    Vecchiola, A.; Fuentes, C.A.; Solar, I.; Lagos, C.F.; Opazo, M.C.; Muñoz-Durango, N.; Riedel, C.A.; Owen, G.I.; Kalergis, A.M.; Fardella, C.E. (Frontiers Media S.A., 2020-04)
    Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. ...
  • Microtubule retrograde motors and their role in retroviral transport 

    Pietrantoni, Gianfranco; Ibarra-Karmy, Rodrigo; Arriagada, Gloria (MDPI AG, 2020-04)
    Following entry into the host cell, retroviruses generate a dsDNA copy of their genomes via reverse transcription, and this viral DNA is subsequently integrated into the chromosomal DNA of the host cell. Before integration ...
  • Fasciola hepatica coinfection modifies the morphological and immunological features of Echinococcus granulosus cysts in cattle 

    Hidalgo, C.; Stoore, C.; Hernández, M.; Paredes, R. (BioMed Central Ltd., 2020-06)
    Polyparasitism occurs when animals harbour multiple parasites concomitantly. It is a common occurrence but is generally understudied in wild and domestic animals. Fasciola hepatica and Echinococcus granulosus, which are ...
  • Draft Genome Sequence of Blautia luti DSM 14534T, Isolated from Human Stool 

    Ortiz, R.L.; Melis-Arcos, F.; Covarrubias, P.C.; Ugalde, J.A.; Apte, Z.S.; Pérez-Donoso, J.; Cárdenas, J.P.; Almonacid, D.E. (American Society for Microbiology, 2020-05)
    Here, we report the draft sequence of Blautia luti strain DSM 14534T, originally isolated from human feces. This draft contains 74 contigs, comprising 3,718,760 bp with a GC content of 42.87%. The annotated draft contains ...
  • Limited life cycle and cost assessment for the bioconversion of lignin-derived aromatics into adipic acid 

    van Duuren, J.B.J.H.; de Wild, P.J.; Starck, S.; Bradtmöller, C.; Selzer, M.; Mehlmann, K.; Schneider, R.; Kohlstedt, M.; Poblete-Castro, I.; Stolzenberger, J.; Barton, N.; Fritz, M.; Scholl, S.; Venus, J.; Wittmann, C. (John Wiley and Sons Inc., 2020-05)
    Lignin is an abundant and heterogeneous waste byproduct of the cellulosic industry, which has the potential of being transformed into valuable biochemicals via microbial fermentation. In this study, we applied a fast-pyrolysis ...
  • Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells 

    Pérez-Moreno, Pablo; Indo, Sebastian; Niechi, Ignacio; Huerta, Hernán; Cabello, Pablo; Jara, Lilian; Aguayo, Francisco; Varas-Godoy, Manuel; Burzio, Verónica A.; Tapia, Julio C. (John Wiley and Sons Ltd., 2020-02)
    Endothelin-1 is a mitogenic peptide that activates several proliferation, survival, and invasiveness pathways. The effects of endothelin-1 rely on its activation by endothelin-converting enzyme-1 (ECE1), which is expressed ...
  • Protective effect of angiotensin 1–7 on sarcopenia induced by chronic liver disease in mice 

    Aguirre, F.; Abrigo, J.; Gonzalez, F.; Gonzalez, A.; Simon, F.; Cabello-Verrugio, C. (MDPI AG, 2020-04)
    Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
  • TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death 

    Ramírez Barrantes, R.; Carvajal Zamorano K., K.; Rodríguez, B.; Córdova, C.; Lozano, C.; Simón, F.; Díaz, P.; Muñoz, P.; Marchant, I.; Latorre, R.; Castillo, K.; Olivero, P. (Frontiers Media S.A., 2020-05)
    17β-estradiol is a neuronal survival factor against oxidative stress that triggers its protective effect even in the absence of classical estrogen receptors. The polymodal transient receptor potential vanilloid subtype 1 ...
  • Quantum entanglement in physical and cognitive systems: A conceptual analysis and a general representation 

    Aerts, D.; Aerts Arguëlles, J.; Beltran, L.; Geriente, S.; Sassoli de Bianchi, M.; Sozzo, S.; Veloz, T. (Springer Verlag, 2019-10)
    We provide a general description of the phenomenon of entanglement in bipartite systems, as it manifests in micro and macro physical systems, as well as in human cognitive processes. We do so by observing that when genuine ...
  • Worldwide occurrence of haemoplasmas in wildlife: Insights into the patterns of infection, transmission, pathology and zoonotic potential 

    Millán, Javier; Di Cataldo, Sophia; Volokhov, Dmitriy V.; . Becker, Daniel J (Blackwell Publishing Ltd, 2020-11)
    Haemotropic mycoplasmas (haemoplasmas) have increasingly attracted the attention of wildlife disease researchers due to a combination of wide host range, high prevalence and genetic diversity. A systematic review identified ...
  • Endothelial dysfunction in pregnancy metabolic disorders 

    Echeverria, Cesar; Eltit, Felipe; Santibanez, Juan F; Gatica, Sebastian; Cabello-Verrugio, Claudio; Simon, Felipe (Elsevier B.V., 2020-02)
    In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by ...
  • Copy number variants in lipid metabolism genes are associated with gallstones disease in men 

    Pérez-Palma, Eduardo; Bustos, Bernabé I.; La, Dennis; Buch, Stephan; Azocar, Lorena; Reza Toliat, Mohammad; Lieb, Wolfgang; Franke, Andre; Hinz, Sebastian; Burmeister, Greta; von Shönfels, Witigo; Schafmayer, Clemens; Ahnert, Peter; Völzke, Henry; Völker, Uwe; Homuth, Georg; Lerch, Markus M.; Puschel, Klaus; Gutiérrez, Rodrigo A; Hampe, Jochen; Nürnberg, Peter; Miquel, Juan Francisco; De Ferrar, Giancarlo V. (Springer Nature, 2020-02)
    Gallstones Disease (GSD) is one of the most common digestive diseases requiring hospitalization and surgical procedures in the world. GSD has a high prevalence in populations with European or Amerindian ancestry (10–20%) ...
  • Myosin va brain-specific mutation alters mouse behavior and disrupts hippocampal synapses 

    Pandian, Swarna; Zhao, Jian-Ping; Murata, Yasunobu; Bustos, Fernando J.; Tunca, Cansu; Almeida, Ramiro D.; Constantine-Paton, Martha (Society for Neuroscience, 2020-11)
    Myosin Va (MyoVa) is a plus-end filamentous-actin motor protein that is highly and broadly expressed in the vertebrate body, including in the nervous system. In excitatory neurons, MyoVa transports cargo toward the tip of ...
  • Divergence in Plant Traits and Increased Modularity Underlie Repeated Transitions Between Low and High Elevations in the Andean Genus Leucheria 

    Pérez, F.; Lavandero, N.; Ossa, CG.; Hinojosa, LF.; Jara-Arancio, P.; Arroyo, MTK. (Frontiers Media S.A., 2020-06)
    Understanding why some plant lineages move from one climatic region to another is a mayor goal of evolutionary biology. In the southern Andes plant lineages that have migrated along mountain ranges tracking cold-humid ...
  • Comprehensive genome analyses of sellimonas intestinalis, a potential biomarker of homeostasis gut recovery 

    Muñoz, Marina; Guerrero-Araya, Enzo; Cortés-Tapia, Catalina; Plaza-Garrido, Angela; Lawley, Trevor D.; Paredes-Sabja, Daniel (Microbiology Society, 2020)
    Sellimonas intestinalis is a Gram-positive and anaerobic bacterial species previously considered as uncultivable. Although little is known about this Lachnospiraceae family member, its increased abundance has been reported ...

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