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Identification of Novel Components of the Unfolded Protein Response in Arabidopsis

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dc.contributor.author Hossain, MA
dc.contributor.author Henriquez-Valencia, C
dc.contributor.author Gomez-Paez, M
dc.contributor.author Medina, J
dc.contributor.author Orellana, A
dc.contributor.author Vicente-Carbajosa, J
dc.contributor.author Zouhar, J
dc.date.accessioned 2016-06-21T15:15:34Z
dc.date.available 2016-06-21T15:15:34Z
dc.date.issued 2016
dc.identifier.citation Front. Plant Sci., 12 May 2016 es
dc.identifier.issn 1664-462X
dc.identifier.other http://dx.doi.org/10.3389/fpls.2016.00650
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/823
dc.description Indexación: Web of Science es
dc.description.abstract Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER. In this study, we systematically screened a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors for resistance toward UPR-inducing chemicals. We identified 23 candidate genes that may function as novel regulators of the UPR and of which only three genes (bZIP10, TBF1, and NF-YB3) were previously associated with the UPR. The putative role of identified candidate genes in the UPR signaling is supported by favorable expression patterns in both developmental and stress transcriptional analyses. We demonstrated that WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses. es
dc.description.uri http://journal.frontiersin.org/article/10.3389/fpls.2016.00650/full
dc.language.iso en es
dc.publisher FRONTIERS MEDIA es
dc.subject GENE-EXPRESSION es
dc.subject SALT STRESS es
dc.subject ER STRESS es
dc.subject MESSENGER-RNA es
dc.subject UBIQUITIN LIGASE es
dc.subject IRE1 es
dc.subject THALIANA es
dc.title Identification of Novel Components of the Unfolded Protein Response in Arabidopsis es
dc.type Article es

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