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Retinoic acid as a modulator of T cell immunity

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dc.contributor.author Bono, M.R.
dc.contributor.author Tejon, G.
dc.contributor.author Flores-Santibañez, F
dc.contributor.author Fernandez, D.
dc.contributor.author Rosemblatt, M.
dc.contributor.author Sauma, D.
dc.date.accessioned 2016-06-23T13:45:53Z
dc.date.available 2016-06-23T13:45:53Z
dc.date.issued 2016
dc.identifier.citation Nutrients 2016, 8(6), 349 es
dc.identifier.issn 2072-6643
dc.identifier.other doi:10.3390/nu8060349
dc.identifier.uri http://repositorio.unab.cl/xmlui/handle/ria/834
dc.description Indexación: Scopus. DOAJ. es
dc.description.abstract Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surface integrity, erythrocyte production, reproduction, and normal immune function. Vitamin A deficiency is one of the most common micronutrient deficiencies worldwide and is associated with defects in adaptive immunity. Reports from epidemiological studies, clinical trials and experimental studies have clearly demonstrated that vitamin A plays a central role in immunity and that its deficiency is the cause of broad immune alterations including decreased humoral and cellular responses, inadequate immune regulation, weak response to vaccines and poor lymphoid organ development. In this review, we will examine the role of vitamin A in immunity and focus on several aspects of T cell biology such as T helper cell differentiation, function and homing, as well as lymphoid organ development. Further, we will provide an overview of the effects of vitamin A deficiency in the adaptive immune responses and how retinoic acid, through its effect on T cells can fine-tune the balance between tolerance and immunity. es
dc.description.uri http://www.mdpi.com/2072-6643/8/6/349
dc.language.iso en es
dc.publisher MDPI AG es
dc.subject Retinoic acid es
dc.subject Vitamin A es
dc.subject T cell es
dc.subject Oral tolerance es
dc.subject Homing es
dc.title Retinoic acid as a modulator of T cell immunity es
dc.type Article es

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