A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe
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Fecha
2019-11-08
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en
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eLife
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Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Transmissible cancers, in which cancer cells themselves act as an infectious agent, have
been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated
neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis
in South America and M. edulis in Europe). Sequencing alleles from four loci (two nuclear and two
mitochondrial) provided evidence of transmissible cancer in both species. Phylogenetic analysis of
cancer-associated alleles and analysis of diagnostic SNPs showed that cancers in both species likely
arose in a third species of mussel (M. trossulus), but these cancer cells are independent from the
previously identified transmissible cancer in M. trossulus from Canada. Unexpectedly, cancers from
M. chilensis and M. edulis are nearly identical, showing that the same cancer lineage affects both.
Thus, a single transmissible cancer lineage has crossed into two new host species and has been
transferred across the Atlantic and Pacific Oceans and between the Northern and Southern
hemispheres
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Citación
eLife Volume 8 November 2019 Article number e47788
DOI
10.1534/g3.119.400204