Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi
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Fecha
2009-04-14
Profesor/a Guía
Facultad/escuela
Idioma
en
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Editor
Public Library of Science
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Licencia CC
CC BY 4.0 DEED
Atribución 4.0 Internacional
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi. © 2009 Retamal et al.
Notas
INDEXACIÓN: SCOPUS.
Palabras clave
Bacterial Proteins, Cation Transport Proteins, Conserved Sequence, Genes, Bacterial, Genes, Reporter, Magnesium, Phenotype, Salmonella typhi, Virulence Factors
Citación
PLoS ONE, Volume 4, Issue 5, 14 May 2009, Article number e5551
DOI
10.1371/journal.pone.0005551