Estrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseases
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Fecha
2022-09
Profesor/a Guía
Facultad/escuela
Idioma
en
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ISSN de la revista
Título del volumen
Editor
Frontiers Media S.A.
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality
worldwide. Epidemiological studies indicate that pre-menopausal women are
more protected against the development of CVDs compared to men of the
same age. This effect is attributed to the action/effects of sex steroid hormones
on the cardiovascular system. In this context, estrogen modulates
cardiovascular function in physiological and pathological conditions, being
one of the main physiological cardioprotective agents. Here we describe the
common pathways and mechanisms by which estrogens modulate the
retrograde and anterograde communication between the nucleus and
mitochondria, highlighting the role of genomic and non-genomic pathways
mediated by estrogen receptors. Additionally, we discuss the presumable role
of bromodomain-containing protein 4 (BRD4) in enhancing mitochondrial
biogenesis and function in different CVD models and how this protein could
act as a master regulator of estrogen protective activity. Altogether, this review
focuses on estrogenic control in gene expression and molecular pathways, how
this activity governs nucleus-mitochondria communication, and its projection
for a future generation of strategies in CVDs treatment.
Notas
Indexación: Scopus.
Palabras clave
Estrogens, Nucleus, Mitochondria, Cardiovascular Diseases, Cardiac Hypertrophy, Heart Failure
Citación
Frontiers in Cell and Developmental Biology. Volume 10. 14 September 2022. Article number 968373
DOI
10.3389/fcell.2022.968373