Characterization of an agarophyton chilense oleoresin containing pparĪ³ natural ligands with insulin-sensitizing effects in a c57bl/6j mouse model of diet-induced obesity and antioxidant activity in caenorhabditis elegans
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Fecha
2021-05
Profesor/a GuĆa
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Idioma
en
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MDPI
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Licencia CC
AtribuciĆ³n 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
The biomedical potential of the edible red seaweed Agarophyton chilense (formerly Gracilaria chilensis) has not been explored. Red seaweeds are enriched in polyunsaturated fatty acids and eicosanoids, which are known natural ligands of the PPARĪ³ nuclear receptor. PPARĪ³ is the molecular target of thiazolidinediones (TZDs), drugs used as insulin sensitizers to treat type 2 diabetes mellitus. Medical use of TZDs is limited due to undesired side effects, a problem that has triggered the search for selective PPARĪ³ modulators (SPPARMs) without the TZD side effects. We produced Agarophyton chilense oleoresin (GracilexĀ®), which induces PPARĪ³ activation without in-ducing adipocyte differentiation, similar to SPPARMs. In a diet-induced obesity model of male mice, we showed that treatment with GracilexĀ® improves insulin sensitivity by normalizing altered glucose and insulin parameters. GracilexĀ® is enriched in palmitic acid, arachidonic acid, oleic acid, and lipophilic antioxidants such as tocopherols and Ī²-carotene. Accordingly, GracilexĀ® possesses antioxidant activity in vitro and increased antioxidant capacity in vivo in Caenorhabditis elegans. These findings support the idea that GracilexĀ® represents a good source of natural PPARĪ³ ligands and antioxidants with the potential to mitigate metabolic disorders. Thus, its nutraceutical value in humans warrants further investigation. Ā© 2021 by the author. Licensee MDPI, Basel, Switzerland.
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IndexaciĆ³n: Scopus
Palabras clave
Agarophyton chilense, Anti-oxidants, Caenorhabditis elegans, GracilexĀ®, Insulin resistance, Natural lipids, PPARĪ³
CitaciĆ³n
Nutrients Volume 13, Issue 6June 2021 Article number 1828
DOI
10.3390/nu13061828