Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation
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Fecha
2017-08
Profesor/a Guía
Facultad/escuela
Idioma
en
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Título del volumen
Editor
American Institute of Physics Inc.
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely "PF-400J", was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.
Notas
Indexación: Web of Science; Scopus.
Palabras clave
BEAM EMISSION, ENERGY
Citación
AIP Advances. Volume 7, Issue 8, 1 August 2017, Article number 085121