Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles
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Fecha
2014-02
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
American Society for Microbiology
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were released to cell supernatants. The viral nucleoprotein was not required for particle formation. Further, a Gc endodomain deletion mutant did not abrogate VLP formation. The VLPs were pleomorphic, exposed protrusions and reacted with patient sera.
Notas
Indexación: Scopus.
Palabras clave
Hantavirus, Virología, Puumala (PUUV), ANDV
Citación
Journal of Virology. Volume 88, Issue 4, Pages 2344 - 2348. February 2014
DOI
10.1128/JVI.03118-13