The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase
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Fecha
2014
Profesor/a Guía
Facultad/escuela
Idioma
en
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Nombre de Curso
Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function. © 2014 Federation of European Biochemical Societies. All rights reserved.
Notas
Indexación: Scopus
Palabras clave
E3-ubiquitin ligase, Evolution, Muscle-specific RING finger family, Novel MuRF, MuRF4, Retrotransposition, Striated muscle
Citación
DOI
10.1016/j.febslet.2014.10.008