Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
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Archivos
Fecha
2013
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Hindawi Limited
Nombre de Curso
Licencia CC
Attribution 3.0 Unported (CC BY 3.0)
Licencia CC
https://www.hindawi.com/journals/jir/2013/210506/#copyright
Resumen
One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance.
Notas
Indexación: Scopus.
Palabras clave
Nephrology, Kidney Transplantation, Hamburgers
Citación
Clinical and Developmental Immunology, Volume 2013, 2013, Article number 210506
DOI
10.1155/2013/210506