Contribution of autophagy to antiviral immunity
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Archivos
Fecha
2015-05
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier B.V.
Nombre de Curso
Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Although identified in the 1960's, interest in autophagy has significantly increased in the past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. Autophagy is commonly defined as a "self-eating" process evolved by eukaryotic cells to recycle senescent organelles and expired proteins, which is significantly increased during cellular stress responses. In addition, autophagy can also play important roles during human diseases, such as cancer, neurodegenerative and autoimmune disorders. Furthermore, novel findings suggest that autophagy contributes to the host defense against microbial infections. In this article, we review the role of macroautophagy in antiviral immune responses and discuss molecular mechanisms evolved by viral pathogens to evade this process. A role for autophagy as an effector mechanism used both, by innate and adaptive immunity is also discussed. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Notas
Indexación: Scopus
Palabras clave
Adaptive immunity, Autophagy, Innate immunity, Macroautophagy, Virus
Citación
FEBS Letters Volume 589, Issue 22, Pages 3461 - 34703 May 2015
DOI
10.1016/j.febslet.2015.07.047