Endothelial dysfunction in pregnancy metabolic disorders
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Archivos
Fecha
2020-02
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier B.V.
Nombre de Curso
Licencia CC
Licencia CC
Resumen
In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions. © 2019 Elsevier B.V.
Notas
Palabras clave
Endothelial dysfunction; Metabolic disorders; Pregnancy; Receptors; Transporters
Citación
Biochimica et Biophysica Acta - Molecular Basis of DiseaseOpen Accessb Volume 1866, Issue 21 February 2020 Article number 165414