Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance
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Fecha
2016-09
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Blackwell Publishing Ltd
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Haem-oxygenase-1 (HO-1) is an enzyme responsible for the degradation
of haem that can suppress inflammation, through the production of car bon monoxide (CO). It has been shown in several experimental models
that genetic and pharmacological induction of HO-1, as well as non-toxic
administration of CO, can reduce inflammatory diseases, such as endo toxic shock, type 1 diabetes and graft rejection. Recently, it was shown
that the HO-1/CO system can alter the function of antigen-presenting
cells (APCs) and reduce T-cell priming, which can be beneficial during
immune-driven inflammatory diseases. The molecular mechanisms by
which the HO-1 and CO reduce both APC- and T-cell-driven immunity
are just beginning to be elucidated. In this article we discuss recent find ings related to the immune regulatory capacity of HO-1 and CO at the
level of recognition of pathogen-associated molecular patterns and T-cell
priming by APCs. Finally, we propose a possible regulatory role for HO-1
and CO over the recently described mitochondria-dependent immunity.
These concepts could contribute to the design of new therapeutic tools
for inflammation-based diseases.
Notas
Indexación: Scopus.
Palabras clave
Antigen Presentation, Carbon Monoxide, Cytokine, Dendritic Cells, Haem-Oxygenase 1
Citación
Immunology. Open Access. Volume 149, Issue 1, Pages 1 - 12. 1 September 2016
DOI
10.1111/imm.12605