Evaluación de características citomorfológicas y predicción de la evolución de frotis (ASC). Score citomorfológico.
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Fecha
2010
Profesor/a Guía
Facultad/escuela
Idioma
es
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Universidad Andrés Bello
Nombre de Curso
Licencia CC
Licencia CC
Resumen
(Atypical Squamous Cells) es una sigla utilizada en citopatología ginecológica para referirse a aquellos frotis en los que no se sabe interpretar con exactitud la benignidad ó malignidad de las células escamosas alteradas presentes en él.
Uno de los puntos más polémicos en el análisis de los ASC es la falta de criterios objetivos para su interpretación, lo que provoca una pobre reproducibilidad entre observadores debido principalmente a que las características citomorfológicas no son claras y no orientan la causa de las atipias, no dejando otra alternativa que repetir el examen.
Se evaluaron 7 características citomorfológicas de células escamosas atípicas, en 229 Papanicolaou interpretados previamente como atípico entre los años 1999 y 2009, de pacientes entre los 17 y 91 años del Hospital Clínico FUSAT en Rancagua, con el objetivo de predecir su evolución utilizando el score citomorfológico propuesto por este estudio.
La sensibilidad del score fue de un 75 y 68%, la especificidad de un 98 y 97%, Valor Predictivo Positivo de un 88 y 84% y un Valor Predictivo Negativo de un 98 y 93% para el observador 1 y observador 2 respectivamente.
El score citomorfológico predijo la evolución de los ASC de un 93% de los PAP atípicos evaluados con una correlación del 82.2% entre ambos observadores.
PALABRAS CLAVE: Papanicolaou atípico, ASC, score citomorfológico.
(Atypical Squamous Cells) is an acronym used in gynecologic cytopathology to refer to those smears where it is not known accurately interpret the benignity or malignancy of the altered squamous cells present in it. One of the most controversial points in the analysis of the ASC is the lack of objective criteria for interpretation, causing poor reproducibility between observers mainly because the cytomorphologic features are not clear and do not guide the cause of atypical, not letting to another alternative that repeat the exam. We evaluated 7 Features cytomorphology of atypical squamous cells, in 229 previously interpreted as atypical Pap between 1999 and 2009, patients between 17 and 91 years of FUSAT Clinical Hospital in Rancagua, in order to predict its evolution using the score cytomorphological proposed by this study. The sensitivity of the score was 75 and 68%, specificity of 98 and 97%, positive predictive value of 88 and 84% and a negative predictive value of 98 and 93% for observer 1 and observer 2, respectively. The cytomorphological score predicted the development of the ASC in 93% of atypical PAP assessed with a 82.2% correlation between both observers. KEY WORDS: Atypícal Papanicolaou smear, ASC, cytomorphological score.
(Atypical Squamous Cells) is an acronym used in gynecologic cytopathology to refer to those smears where it is not known accurately interpret the benignity or malignancy of the altered squamous cells present in it. One of the most controversial points in the analysis of the ASC is the lack of objective criteria for interpretation, causing poor reproducibility between observers mainly because the cytomorphologic features are not clear and do not guide the cause of atypical, not letting to another alternative that repeat the exam. We evaluated 7 Features cytomorphology of atypical squamous cells, in 229 previously interpreted as atypical Pap between 1999 and 2009, patients between 17 and 91 years of FUSAT Clinical Hospital in Rancagua, in order to predict its evolution using the score cytomorphological proposed by this study. The sensitivity of the score was 75 and 68%, specificity of 98 and 97%, positive predictive value of 88 and 84% and a negative predictive value of 98 and 93% for observer 1 and observer 2, respectively. The cytomorphological score predicted the development of the ASC in 93% of atypical PAP assessed with a 82.2% correlation between both observers. KEY WORDS: Atypícal Papanicolaou smear, ASC, cytomorphological score.
Notas
Tesis (Tecnólogo Médico con especialidad en Morfofisiopatología y Citodiagnóstico)
Palabras clave
Cáncer Cérvico - Uterino., Citodiagnóstico., FULL