Biomarkers in Oral Fluids as Diagnostic Tool for Psoriasis
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Fecha
2022-03
Profesor/a Guía
Facultad/escuela
Idioma
en
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Título del volumen
Editor
MDPI
Nombre de Curso
Licencia CC
Attribution 4.0 International (CC BY 4.0)
Licencia CC
https://www.mdpi.com/journal/life/about
Resumen
Psoriasis is a prevalent worldwide chronic immuno-inflammatory skin disease with various variants and atypical cases. The use of biomarkers for the diagnosis of psoriasis can favor timely treatment and thus improve the quality of life of those affected. In general, the search for biomarkers in oral fluids is recommended as it is a non-invasive and fast technique. This narrative review aimed to identify biomarkers in gingival crevicular fluid (GCF) and saliva to diagnose psoriasis. To achieve this goal, we selected the available literature using the following MESH terms: “psoriasis”, “saliva” and “gingival crevicular fluid”. The studies analyzed for this review cover original research articles available in English. We found three full articles available for psoriasis biomarkers in GCF and ten articles available for psoriasis biomarkers in saliva. Studies showed that in the saliva of healthy individuals and those with psoriasis, there were differences in the levels of inflammatory cytokines, immunoglobulin A, and antioxidant biomarkers. In GCF, individuals with psoriasis showed higher levels of S100A8, IL-18 and sE-selectin in comparison to healthy individuals, independent of periodontal status. Despite these findings, more studies are required to determine an adequate panel of biomarkers to use in saliva or GCF for psoriasis.
Notas
Indexación: Scopus.
Palabras clave
biomarkers, gingival crevicular fluid, psoriasis, saliva, Gingival Crevicular Fluid, Neutrophil Collagenase, Biomarkers
Citación
Life, Volume 12, Issue 4, April 2022, Article number 501
DOI
10.3390/life12040501