Cytotoxic Effect of Puya chilensis Collected in Central Chile
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Fecha
2022-04
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
SAGE Publications Inc.
Nombre de Curso
Licencia CC
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Licencia CC
https://us.sagepub.com/en-us/nam/open-access-at-sage
Resumen
This study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC50) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.
Notas
Indexación: Scopus.
Palabras clave
bioactive nutrients, human hepatocellular carcinoma, metabolites, Puya chilensis
Citación
Natural Product Communications, Volume 17, Issue 4, April 2022
DOI
10.1177/1934578X221091671