Modulation of host adaptive immunity by hRSV proteins
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Archivos
Fecha
2014
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Landes Bioscience
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Globally, the human respiratory syncytial virus (hRSV) is
the major cause of lower respiratory tract infections (LRTIs) in
infants and children younger than 2 years old. Furthermore,
the number of hospitalizations due to LRTIs has shown a sus tained increase every year due to the lack of effective vaccines
against hRSV. Thus, this virus remains as a major public health
and economic burden worldwide. The lung pathology devel oped in hRSV-infected humans is characterized by an exac erbated inflammatory and Th2 immune response. In order
to rationally design new vaccines and therapies against this
virus, several studies have focused in elucidating the interac tions between hRSV virulence factors and the host immune
system. Here, we discuss the main features of hRSV biology,
the processes involved in virus recognition by the immune
system and the most relevant mechanisms used by this patho gen to avoid the antiviral host response.
Notas
Indexación: Scopus.
Palabras clave
Respiratory Syncytial Cirus, Virulence Proteins, Innate Immune Response, Adaptive Immune Response
Citación
Virulence. Volume 5, Issue 7, Pages 740 - 751. 2014
DOI
10.4161/viru.32225