Synthesis and antitumor activity of diterpenylhydroquinone derivatives of natural ent-labdanes
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Date
2010-09
Profesor/a GuÃa
Facultad/escuela
Idioma
en
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Nombre de Curso
item.page.dc.rights
Attribution 3.0 Unported (CC BY 3.0)
item.page.dc.rights
https://creativecommons.org/licenses/by/3.0/
Abstract
Two new compounds 2β-acetoxy-15-phenyl-(22,25-acetoxy)-ent-labda-8(17) , 13(E)-diene (9) and 2β-hydroxy-15-phenyl-(22,24,26-trimethoxy)-ent-labda- 8(17),13(E)-diene (10) have been prepared by an Electrophilic Aromatic Substitution (EAS) reaction between diterpenyl allylic alcohols and 1,4-hydroquinone or 1,3,5-trimethoxybenzene using BF3·Et 2O as a catalyst. These compounds, along with a series of natural ent-labdanes 3-8, have been evaluated for their in vitro cytotoxic activities against cultured human cancer cells of PC-3 and DU-145 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma and dermal human fibroblasts (DHF). Some compounds displayed inhibition at μM IC50 values. © 2010 by the authors.
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Indexación: Scopus
Keywords
Antitumoral activity, Diterpenylhydroquinones, Ent-labdanes
Citation
Molecules Volume 15, Issue 9, Pages 6502 - 6511September 2010
DOI
10.3390/molecules15096502