Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review
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Fecha
2023-07
Profesor/a Guía
Facultad/escuela
Idioma
en
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Editor
Multidisciplinary Digital Publishing Institute (MDPI)
Nombre de Curso
Licencia CC
CC BY 4.0 Attribution 4.0 International Deed
Licencia CC
https://creativecommons.org/licenses/by/4.0/
Resumen
This comprehensive narrative review explores the concept of neuro-vulnerability in energy metabolism regulation and its implications for metabolic disorders. The review highlights the complex interactions among the neural, hormonal, and metabolic pathways involved in the regulation of energy metabolism. The key topics discussed include the role of organs, hormones, and neural circuits in maintaining metabolic balance. The review investigates the association between neuro-vulnerability and metabolic disorders, such as obesity, insulin resistance, and eating disorders, considering genetic, epigenetic, and environmental factors that influence neuro-vulnerability and subsequent metabolic dysregulation. Neuroendocrine interactions and the neural regulation of food intake and energy expenditure are examined, with a focus on the impact of neuro-vulnerability on appetite dysregulation and altered energy expenditure. The role of neuroinflammation in metabolic health and neuro-vulnerability is discussed, emphasizing the bidirectional relationship between metabolic dysregulation and neuroinflammatory processes. This review also evaluates the use of neuroimaging techniques in studying neuro-vulnerability and their potential applications in clinical settings. Furthermore, the association between neuro-vulnerability and eating disorders, as well as its contribution to obesity, is examined. Potential therapeutic interventions targeting neuro-vulnerability, including pharmacological treatments and lifestyle modifications, are reviewed. In conclusion, understanding the concept of neuro-vulnerability in energy metabolism regulation is crucial for addressing metabolic disorders. This review provides valuable insights into the underlying neurobiological mechanisms and their implications for metabolic health. Targeting neuro-vulnerability holds promise for developing innovative strategies in the prevention and treatment of metabolic disorders, ultimately improving metabolic health outcomes. © 2023 by the authors.
Notas
Indexación: Scopus
Palabras clave
Eating Disorders, Energy Metabolism, Metabolic Disorders, Neuro-Vulnerability, Neurobiological Mechanisms, Neuroendocrine Interactions, Neuroimaging Techniques, Neuroinflammation, Obesity
Citación
Nutrients. Volume 15, Issue 14. July 2023. Article number 3106
DOI
10.3390/nu15143106