Lichens: might be considered as a source of gastroprotective molecules?
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Fecha
2013
Profesor/a Guía
Facultad/escuela
Idioma
en
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ISSN de la revista
Título del volumen
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Nombre de Curso
Licencia CC
Licencia CC
Resumen
ABSTRACT
Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
Keywords: Lichens; depside; depsidone; gastric ulcer;
Notas
Indexación: Web of Science; Scielo
Palabras clave
Lichens; depside; depsidone; gastric ulcer;
Citación
Journal of the Chilean Chemical Society. Vol. 58 N° 2, 2013.