Pharmacological treatment for challenging behavior in adults with intellectual disability: Systematic review and meta-analysis
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Fecha
2023-01
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Sociedad Española de Psiquiatría and Sociedad Española de Psiquiatría Biológica
Nombre de Curso
Licencia CC
Attribution-NonCommercial-NoDerivatives 4.0 International
Licencia CC
Resumen
Introduction
Few evidence on the use of antipsychotics in people with intellectual disabilities and challenging behaviors, generates the need to develop studies that contribute to collect, compare and synthesize the available information. The present systematic review and meta-analysis aims to determine the clinical efficacy of antipsychotic medication in reducing critical episodes in this population.
Methods
We searched Web of Science, Scopus, EBSCO, Embase, and PubMed for randomized controlled trials of antipsychotic medication versus placebo. Preliminarily yielded 1354 abstracts and citations; six studies with 274 subjects met the inclusion criteria of studies with experimental design, longitudinal type, with pre- and post-intervention measurements.
Results
There is evidence for the use of psychotropic drugs in the acute management of challenging behaviors in patients with intellectual disability (SMD = −0.85; 95% CI = −1.69 to −0.01; p = 0.05).
Conclusions
Our results coincide with the recommendations on the efficacy of the use of antipsychotics. Although our study provides evidence, the limited number of studies included in this research does not allow us to obtain totally conclusive results, although it can be considered as a guide for future studies.
Notas
TEXTO COMPLETO EN INGLÉS
Palabras clave
Intellectual disability, Challenging behavior, Pharmacological treatment
Citación
Revista de Psiquiatría y Salud Mental, Available online 31 January 2023
DOI
https://doi.org/10.1016/j.rpsm.2023.01.003