New catechol derivatives of safrole and their antiproliferative activity towards breast cancer cells
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Fecha
2011-06
Profesor/a Guía
Facultad/escuela
Idioma
en
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Editor
MDPI
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Licencia CC
Attribution 3.0 Unported (CC BY 3.0)
Licencia CC
https://creativecommons.org/licenses/by/3.0/
Resumen
Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The derivatives 4-allylbenzene-1,2-diol (3), 4 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (6) and 4-[3-(acetyloxy)propyl]- 5-nitro-1,2-phenylene diacetate (10) showed higher cytotoxicity than the parent compound 2 in tests performed on two breast cancer cell lines (MCF-7 and MDA-MB-231). The IC50 values of 40.2 ± 6.9 μM, 5.9 ± 0.8 μM and 33.8 ± 4.9 μM, respectively, were obtained without toxicity towards dermal human fibroblast (DHF cells). © 2011 by the authors; licensee MDPI, Basel, Switzerland.
Notas
Indexación: Scopus
Palabras clave
Antiproliferative activity, Catechol, Synthesis
Citación
Molecules Volume 16, Issue 6, Pages 4632 - 4641June 2011
DOI
10.3390/molecules16064632