Desarrollo de formulaciones magistrales para su incorporaciĆ³n a recetario magistral de Farmacias Salcobrand
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Archivos
Fecha
2023
Autores
Profesor/a GuĆa
Facultad/escuela
Idioma
es
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Editor
Universidad AndrƩs Bello
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Los preparados magistrales son formulaciones que se elaboran de forma personalizada para cada paciente, segĆŗn las necesidades especĆficas de su tratamiento en base a lo prescrito por un profesional legalmente habilitado. Estos productos permiten a los profesionales de la salud personalizar la dosis, la forma farmacĆ©utica, los componentes y la vĆa de administraciĆ³n de un medicamento considerando circunstancias especiales no cubiertas por los productos presentes en el mercado. Esto puede ser crucial ademĆ”s para aquellos pacientes que no pueden recibir las presentaciones comerciales debido a condiciones como alergias, intolerancias o afecciones mĆ©dicas especĆficas.
En este sentido, el presente trabajo tuvo como objetivo principal el desarrollo de formulaciones magistrales con el fin de incorporarlas a recetario magistral de farmacias Salcobrand, respondiendo a las necesidades que han sido comunicadas por profesionales mĆ©dicos. La instituciĆ³n y su departamento de desarrollo buscan la factibilidad de elaboraciĆ³n de nuevas formulaciones considerando la vehiculizaciĆ³n de anestĆ©sicos locales para brindar una nueva alternativa en los procedimientos de mesoterapia y lĆ”ser de CO2 con la posible mejorĆa de su biodisponibilidad a nivel tĆ³pico, y una segunda formulaciĆ³n que contemple el mejoramiento estĆ©tico de una crema de Ćcido retinoico utilizada como peeling facial. La metodologĆa se basĆ³ en un estudio no experimental que involucrĆ³ la selecciĆ³n de las bases y definiciĆ³n de las concentraciones de los activos a incluir en las propuestas de formulaciones, sustentĆ”ndose en los resultados de una bĆŗsqueda bibliogrĆ”fica. Las formulaciones definitivas fueron elegidas bajo el criterio de factibilidad de elaboraciĆ³n, aceptaciĆ³n tras pruebas de control de calidad del producto final y la aprobaciĆ³n de los estudios de estabilidad. Posteriormente, se procediĆ³ a crear el soporte documental propio de las formulaciones utilizando el formato de fichas tĆ©cnicas que permiten la reproducibilidad del preparado.
Se logra de esta forma el desarrollo de estos nuevos productos y su incorporaciĆ³n entre las alternativas disponibles para el tratamiento de los pacientes en el recetario magistral de Salcobrand, respondiendo a lo solicitado por el equipo de desarrollo de dicha instituciĆ³n y el personal mĆ©dico.
Magistral preparations are formulations elaborated in a personalized manner for each patient, according to patientsā specific needs as prescribed by a legally authorized professional. These products allow healthcare professionals to customize medication dosage, pharmaceutical form, components, and administration route, considering special circumstances not covered by medications available in the market. This can be crucial for patients unable to receive commercial presentations due to conditions such as allergies, intolerances, or specific medical conditions. In this context, the main objective of this work is the development of magistral formulations to be incorporated into Salcobrand pharmacy's compounding formulary, addressing the needs communicated by medical professionals. The institution and its development department aim to explore the feasibility of creating new formulations, considering the delivery of local anesthetics to provide a new alternative in mesotherapy and CO2 laser procedures, potentially improving their topical bioavailability. A second formulation aims to enhance the aesthetic improvement of a retinoic acid cream used for facial peeling. The methodology was based on a non-experimental study involving the selection of bases and defining concentrations of active ingredients to be included in the proposed formulations, supported by the results of a literature search. The final formulations were chosen based on feasibility of preparation, acceptance after quality control tests of the final product, and approval of stability studies. Subsequently, the documentation supporting these formulations was created using technical sheets to ensure the reproducibility of the preparation. It was achieved the development of these new products and their inclusion among the available alternatives for patient treatment in Salcobrand's compounding formulary, addressing the requests made by the development team of said institution and medical personnel. Key words: Magistral formulation, local anesthetic, retinoic acid, magistral prescription, development, emulsion.
Magistral preparations are formulations elaborated in a personalized manner for each patient, according to patientsā specific needs as prescribed by a legally authorized professional. These products allow healthcare professionals to customize medication dosage, pharmaceutical form, components, and administration route, considering special circumstances not covered by medications available in the market. This can be crucial for patients unable to receive commercial presentations due to conditions such as allergies, intolerances, or specific medical conditions. In this context, the main objective of this work is the development of magistral formulations to be incorporated into Salcobrand pharmacy's compounding formulary, addressing the needs communicated by medical professionals. The institution and its development department aim to explore the feasibility of creating new formulations, considering the delivery of local anesthetics to provide a new alternative in mesotherapy and CO2 laser procedures, potentially improving their topical bioavailability. A second formulation aims to enhance the aesthetic improvement of a retinoic acid cream used for facial peeling. The methodology was based on a non-experimental study involving the selection of bases and defining concentrations of active ingredients to be included in the proposed formulations, supported by the results of a literature search. The final formulations were chosen based on feasibility of preparation, acceptance after quality control tests of the final product, and approval of stability studies. Subsequently, the documentation supporting these formulations was created using technical sheets to ensure the reproducibility of the preparation. It was achieved the development of these new products and their inclusion among the available alternatives for patient treatment in Salcobrand's compounding formulary, addressing the requests made by the development team of said institution and medical personnel. Key words: Magistral formulation, local anesthetic, retinoic acid, magistral prescription, development, emulsion.
Notas
Seminario (QuĆmico FarmacĆ©utico)
Palabras clave
Recetario Magistral, Prescripciones de Medicamentos, Preparaciones FarmacƩuticas