Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type i and type II diabetes mellitus: A systematic review and meta-Analysis

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Fecha
2023-11
Profesor/a Guía
Facultad/escuela
Idioma
en
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ISSN de la revista
Título del volumen
Editor
Lippincott Williams and Wilkins
Nombre de Curso
Licencia CC
Attribution 4.0 International Deed (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/
Resumen
Background: This systematic review explores the most current evidence regarding the mechanisms of neuropathic pain in patients with different types of diabetes and how this pain affects different functional and structural components of the neuroanatomical pain pathways. The review also seeks to provide guidelines for the best approach and treatment for patients experiencing this type of pain. The objective is to determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II. Objective: To determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II. Methods: We systematically search MEDLINE (via PubMed), EMBASE, SCOPUS, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, and Web of Science databases. Results: The findings of this review show that different forms of ALA do not present statistically significant changes for any of the scales included, including total symptom score (standardized mean difference [SMD] =-3.59, confidence interval [CI] =-4.16 to-3.02, and P <.00001), neuropathy impairment score (SMD =-1.42, CI =-3.68 to 0.84, and P =.22), and neuropathy symptom checklist (SMD =-0.09, CI =-0.15 to-0.02, and P =.01). Conclusion: In comparison to the use of a placebo, the findings suggest that ALA does not exhibit significant differences in terms of pain reduction and different functional scales. Moreover, no specific dosages are identified to support the use of ALA for the reduction of neuropathic pain. © 2023 Lippincott Williams and Wilkins. All rights reserved.
Notas
Indexación: Scopus
Palabras clave
Alpha-lipoic Acid, Diabetic Polyneuropathy, Neuropathic Pain, Pharmacology, Polyneuropathy, Type I diabetes mellitus, Type II diabetes mellitus
Citación
Medicine (United States). Volume 102, Issue 44, Pages E35368. 3 November 2023
DOI
10.1097/MD.0000000000035368
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