Monounsaturated fatty acids are substrates for aldehyde generation in tellurite-exposed Escherichia coli
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Archivos
Fecha
2013
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Hindawi
Nombre de Curso
Licencia CC
Attribution 3.0 Unported (CC BY 3.0)
Licencia CC
https://www.hindawi.com/journals/bmri/2013/563756/#copyright
Resumen
Reactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial resistance to oxidative stress elicitors was evaluated. Studies included wild-type cells as well as cells exhibiting a modulated monounsaturated fatty acid (MUFA) ratio. The hydroxyaldehyde 4-hydroxy 2-nonenal was found to be most likely produced by E. coli, whose levels are dependent upon exposure to oxidative stress elicitors. Aldehyde amounts and markers of oxidative damage decreased upon exposure to E. coli containing low MUFA ratios, which was paralleled by a concomitant increase in resistance to ROS-generating compounds. MUFAs ratio, lipid peroxidation, and aldehyde generation were found to be directly related; that is, the lower the MUFAs ratio, the lower the peroxide and aldehyde generation levels. These results provide additional evidence about MUFAs being targets for membrane lipid oxidation and their relevance in aldehyde generation.
Notas
Indexación: Scopus.
Palabras clave
Aldehydes, Escherichia coli, Fatty Acids, Monounsaturated, Membrane Lipids, Oxidation-Reduction, Oxidative Stress, Reactive Oxygen Species, Tellurium
Citación
BioMed Research International, Volume 2013, 2013, Article number 563756
DOI
10.1155/2013/563756