Anti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins
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Fecha
2021-10-01
Profesor/a Guía
Facultad/escuela
Idioma
en
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Elsevier B.V.
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Atribución/Reconocimiento-NoComercial-SinDerivados 4.0 Internacional
CC BY-NC-ND 4.0
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Licencia CC
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Resumen
The proteins connexins, innexins, and pannexins are the subunits of non-selective channels present in the cell membrane in vertebrates (connexins and pannexins) and invertebrates (innexins). These channels allow the transfer of ions and molecules across the cell membrane or, and in many cases, between the cytoplasm of neighboring cells. These channels participate in various physiological processes, particularly under pathophysiological conditions, such as bacterial, viral, and parasitic infections. Interestingly, some anti-parasitic drugs also block connexin- or pannexin-formed channels. Their effects on host channels permeable to molecules that favor parasitic infection can further explain the anti-parasitic effects of some of these compounds. In this review, the effects of drugs with known anti-parasitic activity that modulate non-selective channels formed by connexins or pannexins are discussed. Previous studies that have reported the presence of these proteins in worms, ectoparasites, and protozoa that cause parasitic infections have also been reviewed. © 2021 Elsevier B.V.
Notas
Indexación: Scopus.
Palabras clave
Anti-parasitic drugs, Chagas diseases, Malaria, Neglected tropical diseases, Sleeping sickness
Citación
Biochimica et Biophysica Acta - Molecular Basis of Disease, Volume 1867, Issue 10, 1 October 2021, Article number 166188
DOI
10.1016/j.bbadis.2021.166188