The chaperone ClpC participates in sporulation, motility, biofilm, and toxin production of Clostridioides difficile
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Fecha
2023-06
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier Ltd
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Objectives: Clostridioides difficile is a nosocomial pathogen that is associated with the use of antibiotics.
One of the most worrying aspects of C. difficile infection is its ability to resist antimicrobial therapies,
owing to spore formation. In several bacterial pathogens, proteases of the Clp family participate in phe notypes associated with persistence and virulence. This suggests that these proteins could be involved
in virulence-related traits. In this study, we analysed the role of ClpC chaperone-protease of C. difficile
in virulence-related traits by comparing the phenotypes of wild-type and mutant strains lacking the clpC
gene ( clpC).
Methods: We performed biofilm, motility, spore formation, and cytotoxicity assays.
Results: Our results show significant differences between the wild-type and clpC strains in all analysed
parameters.
Conclusions: Based on these findings, we conclude that clpC plays a role in the virulence properties of C.
difficile.
© 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial
Chemotherapy.
This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
Notas
Indexación: Scopus.
Palabras clave
Clostridioides Difficile, ClpC Chaperone, Virulence Traits
Citación
Journal of Global Antimicrobial Resistance. Volume 33, Pages 328 - 336. June 2023
DOI
10.1016/j.jgar.2023.05.004