Resección ósea guiada por fluorescencia en pacientes con osteonecrosis mandibular asociada a medicamentos: Scoping Review / Roco Bazáez, Joaquín
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Fecha
2020
Profesor/a Guía
Facultad/escuela
Idioma
es
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Editor
Universidad Andrés Bello
Nombre de Curso
Licencia CC
Licencia CC
Resumen
La osteonecrosis mandibular asociada a medicamentos (MRONJ) es una enfermedad grave, pero de baja prevalencia en la cual los márgenes quirúrgicos de la resección ósea son determinados clínicamente por el cirujano basado en parámetros subjetivos. Debido a esto, se ha propuesto la resección ósea guiada por fluorescencia. Objetivo: El objetivo de este estudio es describir el conocimiento actual sobre la resección ósea guiada por fluorescencia en pacientes con MRONJ. Material y Método: Se realizó Scoping Review, buscando en las bases de datos de Pubmed, ScienceDirect y Web of Science, utilizando los operadores booleanos AND y OR. Se aplicaron criterios de inclusion y exclusión. Resultados: De 66 artículos iniciales, se seleccionaron 13 que cumplieron con los criterios de elegibilidad. Discusión: Se utiliza la técnica de fluorescencia con tetraciclinas (FT) y autofluorescencia (AF), describiéndose un éxito del 85 a 100% y 77.3 a 100% en 1 a 12.9 y 4 a 13.1 meses respectivamente. Hubo 100% de correlación Clínico-Histopatológica para tejido óseo vital y necrótico. Conclusión: La resección ósea guiada por fluorescencia logra discriminar clínicamente entre tejido óseo vital y necrótico, permitiendo delimitar los márgenes quirúrgicos, basado en parámetros objetivos y reproducibles. Además, permite estandarizar el procedimiento quirúrgico.
Medication-related Osteonecrosis of the jaw (MRONJ) is a serious but low prevalence disease in which the surgical margins of bone resection are clinically determinated by the surgeon based on subjetive parameters. Because of this, fluorescence-guided bone resection has been proposed. Objetive: The objetive of this study is to describe the current knowledge of fluorescence-guided bone resection in patients with MRONJ. Material and method: Scoping Review was carried out, searching the databases of PubMed, ScienceDirect and Web of Science, using the boolean operator AND and OR. Inclusion and exclusion criteria were applied. Results: Of 66 articles, 13 were selected that met the eligibility criteria. Discussion: The technique of fluorescence with tetracyclines (FT) and autofluorescence (AF) is used, describing a success of 85 to 100% and 77.3 to 100% in 1 to 12.9 and 4 to 13.1 months respectively. There was 100% Clinical-Histopathological correlation for vital and necrotic bone tissue. Conclusion: Fluorescence-guided bone resection is able to clinically discriminate between vital and necrotic bone tissue, allowing the delimitation of surgical margins based on objective and reproducible parameters. In addition, it allows to standardize the surgical procedure.
Medication-related Osteonecrosis of the jaw (MRONJ) is a serious but low prevalence disease in which the surgical margins of bone resection are clinically determinated by the surgeon based on subjetive parameters. Because of this, fluorescence-guided bone resection has been proposed. Objetive: The objetive of this study is to describe the current knowledge of fluorescence-guided bone resection in patients with MRONJ. Material and method: Scoping Review was carried out, searching the databases of PubMed, ScienceDirect and Web of Science, using the boolean operator AND and OR. Inclusion and exclusion criteria were applied. Results: Of 66 articles, 13 were selected that met the eligibility criteria. Discussion: The technique of fluorescence with tetracyclines (FT) and autofluorescence (AF) is used, describing a success of 85 to 100% and 77.3 to 100% in 1 to 12.9 and 4 to 13.1 months respectively. There was 100% Clinical-Histopathological correlation for vital and necrotic bone tissue. Conclusion: Fluorescence-guided bone resection is able to clinically discriminate between vital and necrotic bone tissue, allowing the delimitation of surgical margins based on objective and reproducible parameters. In addition, it allows to standardize the surgical procedure.
Notas
Trabajo de titulación (Cirujano Dentista, Licenciado en Odontología)
Palabras clave
Fluorescencia ósea, Resección Guiada, Osteonecrosis, Medicamentos, Efectos Adversos, Chile