A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins
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Fecha
2014-11
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Nano Letters
Nombre de Curso
Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo. © 2014 American Chemical Society.
Notas
Indexación: Scopus
Palabras clave
biologics, Nanoparticles, solvent-free, therapeutic proteins, thermosponge
Citación
DOI
10.1021/nl502994y