Clemente-Suárez, Vicente JavierMartín-Rodríguez, AlexandraRedondo-Flórez, LauraLópez-Mora, ClaraYáñez-Sepúlveda, RodrigoTornero-Aguilera, José Francisco2023-10-172023-10-172023-07International Journal of Molecular Sciences Open Access Volume 24, Issue 13 July 2023 Article number 1067216616596https://repositorio.unab.cl/xmlui/handle/ria/53482Indexación: Scopus.Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.enAdvanced imaging techniquesCell-based therapiesEpigeneticsGeneticGutMicrobiotaNutritionPhysical activityPsychologySingle-cell transcriptomicsArtículoCC BY 4.0 DEED10.3390/ijms241310672