Escobar, B.Montenegro, I.Villena, J.Werner, E.Godoy, P.Olguín, Y.Madrid, A.2017-11-242017-11-242017-06Molecules. Volume 22, Issue 6, June 2017, Article number 9681420-3049doi:10.3390/molecules22060968http://repositorio.unab.cl/xmlui/handle/ria/4747Indexación: Web of Science; Scopus.An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.enAnti-oomycete activityIsocordoinOxyalkyl derivatesSaprolegnia sp.Artículo