Torres, Cecilia C.Campos, Cristian H.Diáz, CarolaJiménez, Verónica A.Vidal, FelipeGuzmán, LeonardoAlderete, Joel B.2023-09-222023-09-222016-08Materials Science and Engineering C Volume 65, Pages 164 - 1711 August 20160928-4931https://repositorio.unab.cl/xmlui/handle/ria/53284Indexación: ScopusPAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes. © 2016 Elsevier B.V. All rights reserved.enDrug deliveryPAMAM dendrimersSmall molecule drugsTiO2 nanotubesArtículoAtribución 4.0 Internacional (CC BY 4.0)10.1016/j.msec.2016.03.104