Montenegro, IvanTomasoni, GiacomoBosio, ClaudiaQuiñones, NataliaMadrid, AlejandroCarrasco, HectorOlea, AndresMartinez, RolandoCuellar, MauricioVillena, Joan2023-01-032023-01-0320141420-3049https://repositorio.unab.cl/xmlui/handle/ria/35776Indexación: ScopusTwelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.enApoptosisCancer cell linesCaspasa-3 activityCytotoxic activityDrimanesMitochondrial membrane permeabilityNordrimanesSesquiterpenesStudy on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell linesArtículoAtribución 4.0 Internacional (CC BY 4.0)10.3390/molecules191118993