Cruces, PabloRetamal, JaimeHurtado, Daniel E.Erranz, BenjamínIturrieta, PabloGonzález, CarlosDíaz, Franco2022-06-152022-06-152020-08Critical Care Open Access Volume 24, Issue 110 August 2020 Article number 49413648535https://repositorio.unab.cl/xmlui/handle/ria/22846Indexación: Scopus.Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view. © 2020 The Author(s).enCOVID-19Lung strainMechanical ventilationP-SILISARS-CoV2Work of breathingArtículoAttribution 4.0 International (CC BY 4.0)10.1186/s13054-020-03197-7