Fraga, B.Guillermo, R.Hernández, M.Chamy, M.Garbarino, J.2023-07-122023-07-122012-02Molecules, Volume 17, Issue 2, Pages 1744 - 1750, February 20121420-3049https://repositorio.unab.cl/xmlui/handle/ria/51595Indexación: Scopus.The biotransformation of 13α,17-dihydroxystemodane (3) with the fungus Cephalosporium aphidicola afforded 13α,17,18-trihydroxystemodane (4), 3β,13α,17-trihydroxystemodane (5), 13α,17-dihydroxy- stemodan-18-oic acid (6), 3β,11β,13α,17-tetrahydroxystemodane (7), 11β,13α,17,18-tetrahydroxystemodane (8) and 3β,13α, 17,18-tetrahydroxystemodane (9). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (2) is hydroxylated at this carbon. However, the C-3(β) and C-11(β) hydroxylations seem to indicate a xenobiotic biotransformation.enBiotransformationsCephalosporium aphidicolaDiterpenesStemodaneArtículoAttribution 4.0 International (CC BY 4.0)10.3390/molecules17021744