Vásquez-Gómez, JaimeFaúndez-Casanova, Césarde Carvalho, Ricardo SouzaCastillo-Retamal, FranklinReyes, Pedro ValenzuelaConcha-Cisternas, YenyLuna-Villouta, PabloÁlvarez, CristianGodoy-Cumillaf, AndrésHernández-Mosqueira, ClaudioCigarroa, IgorGarrido-Méndez, AlexMatus-Castillo, CarlosCastillo-Retamal, MarceloRibeiro, Ivana Leao2024-04-302024-04-302022-06-01International Journal of Environmental Research and Public Health, Volume 19, Issue 11, June-1 2022, Article number 68561661-7827https://repositorio.unab.cl/handle/ria/56482Indexación: Scopus.COVID-19 causes cardiovascular and lung problems that can be aggravated by confinement, but the practice of physical activity (PA) could lessen these effects. The objective of this study was to evaluate the association of maximum oxygen consumption (VO2 max) with vaccination and PCR tests in apparently healthy Chilean adults. An observational and cross-sectional study was performed, in which 557 people from south-central Chile participated, who answered an online questionnaire on the control of COVID-19, demographic data, lifestyles, and diagnosis of non-communicable diseases. VO2 max was estimated with an abbreviated method. With respect to the unvaccinated, those . who received the first (OR:0.52 [CI:0.29;0.95], p = 0.019) and second vaccine (OR:0.33 [CI:0.18;0.59], p = 0.0001) were less likely to have an increased VO2 max. The first vaccine was inversely associated with VO2 max (mL/kg/min) (β:−1.68 [CI:−3.06; −0.3], p = 0.017), adjusted for BMI (β:−1.37 [CI:−2.71; −0.03], p = 0.044) and by demographic variables (β:−1.82 [CI:−3.18; −0.46], p = 0.009); similarly occur for the second vaccine (β: between −2.54 and −3.44, p < 0.001) on models with and without adjustment. Having taken a PCR test was not significantly associated with VO2 max (mL/kg/min). It is concluded that vaccination significantly decreased VO2 max, although it did not indicate cause and effect. There is little evidence of this interaction, although the results suggest an association, sinceVO2 max could prevent and attenuate the contagion symptoms and effects. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.enAdultCardiorespiratory fitnessPolymerase chain reactionSARS-CoV-2VaccinesArtículoCC BY 4.0 DEED Atribución 4.0 Internacional10.3390/ijerph19116856