Funes, S.C.Rios, M.Fernández-Fierro, A.Covián, C.Bueno, S.M.Riedel, C.A.Mackern-Oberti, J.P.Kalergis, A.M.2021-10-182021-10-182020-07Frontiers in Immunology Open Access Volume 1123 July 2020 Article number 14671664-3224http://repositorio.unab.cl/xmlui/handle/ria/20510Indexación: Scopus.Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity. © Copyright © 2020 Funes, Rios, Fernández-Fierro, Covián, Bueno, Riedel, Mackern-Oberti and Kalergis.enautoimmunityheme oxygenase 1HO-1Inflammationnaturally derived compoundsArtículoAttribution 4.0 International (CC BY 4.0)10.3389/fimmu.2020.01467