Espinoza Catalán, LuisMadrid Villegas, AlejandroTaborga Liber, LautaroVillena García, JoanCuellar Fritis, MauricioCarrasco Altamirano, Héctor2013-10-222016-05-242013-10-222016-05-242010Journal of the Chilean Chemical Society, Vol. 55, N° 2, pp. 219-222, 2010.ISSN: 0717-9707DOI: 10.4067/S0717-97072010000200016http://repositorio.unab.cl/xmlui/handle/ria/1943Indexación: ScieloSafrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).enAntiproliferative activitySafrole derivativesSynthesisArtículo© 2013 Sociedad Chilena de Química