Espinoza, Janyra A.Bohmwald, KarenCéspedes, Pablo F.Céspedes, Pablo F.Bueno, Susan M.Kalergis, Alexis M.2023-07-132023-07-132014Virulence. Volume 5, Issue 7, Pages 740 - 751. 20142150-5594https://repositorio.unab.cl/xmlui/handle/ria/51661Indexación: Scopus.Globally, the human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infections (LRTIs) in infants and children younger than 2 years old. Furthermore, the number of hospitalizations due to LRTIs has shown a sus tained increase every year due to the lack of effective vaccines against hRSV. Thus, this virus remains as a major public health and economic burden worldwide. The lung pathology devel oped in hRSV-infected humans is characterized by an exac erbated inflammatory and Th2 immune response. In order to rationally design new vaccines and therapies against this virus, several studies have focused in elucidating the interac tions between hRSV virulence factors and the host immune system. Here, we discuss the main features of hRSV biology, the processes involved in virus recognition by the immune system and the most relevant mechanisms used by this patho gen to avoid the antiviral host response.enRespiratory Syncytial CirusVirulence ProteinsInnate Immune ResponseAdaptive Immune ResponseArtículoAtribution 4.0 International (CC BY 4.0)10.4161/viru.32225