Salamanca, Constain HBarraza, Raúl G.Acevedo, BetsabéOlea, Andrés F.2013-10-222016-05-242013-10-222016-05-242007Journal of the Chilean Chemical Society, Vol. 52, pp. 1115-1119, 2007.ISSN: 0717-9707DOI: 10.4067/S0717-97072007000100014http://repositorio.unab.cl/xmlui/handle/ria/2036Indexación: ScieloThe solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different length, have been investigated in aqueous solution at pH 3.0, 7.0 and 11.0. Potassium salts of poly(maleic acid-co-1-olefins), PA-nK2 with n ranging from 8 to 18, were used as micelle-forming polymers. The partition of these drugs between water and the hydrophobic microdomains provided by PA-nK2 was studied by the pseudo-phase model to determinate the distribution coefficient KS, and the standard free energy of transfer Δμºt. The results indicate that solubility of alkyl-nitroimidazoles on these polymer micelles depends moderately on the length of the alkyl chain, and therefore is mainly determined by the heterocyclic group. On the other hand, the solubilization of 1-hexyl-2-methyl-4-nitroimidazole increase with decreasing length of the side alkyl chain; i.e. KS follows the order PA-8K2 > PA-10K2 > PA-12K2 > PA-14K2 > PA-16K2 >PA-18K2.PolyelectrolyteMaleic copolymersN-alkyl-nitroimidazolesPartitionDrugs reservoirsArtículo