Sepulveda, BeatrizChamy, María CristinaPiovano, MarisaAreche, Carlos2014-02-242016-05-242014-02-242016-05-242013Journal of the Chilean Chemical Society. Vol. 58 N° 2, 2013.0717-9707http://dx.doi.org/10.4067/S0717-97072013000200024http://repositorio.unab.cl/xmlui/handle/ria/2365Indexación: Web of Science; ScieloABSTRACT Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules. Keywords: Lichens; depside; depsidone; gastric ulcer;enLichens; depside; depsidone; gastric ulcer;Artículo